Publications

Most Recent

  1. Mathias, T. J., Ju, J. A., Lee, R. M., Thompson, K. N., Mull, M. L., Annis, D. A., Chang, K. T., Ory, E. C., Stemberger, M. B., Hotta, T., Ohi, R., Vitolo, M. I., Moutin, M.-J., & Martin, S. S. (2022). Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling. Cancers, 14(7), 1707.
  2. Thompson, K. N., Ju, J. A., Ory, E. C., Pratt, S. J. P., Lee, R. M., Mathias, T. J., Chang, K. T., Lee, C. J., Goloubeva, O. G., Bailey, P. C., Chakrabarti, K. R., Jewell, C. M., Vitolo, M. I., & Martin, S. S. (2022). Microtubule disruption reduces metastasis more effectively than primary tumor growth. Breast Cancer Research, 24(1), 13.
  3. Lee RM, Vitolo, MI, Losert, W, Martin SS. (2021). Distinct roles of tumor associated mutations in collective cell migration. Sci Rep. 11(1):10291.
  4. Bhandary L, Bailey PC, Chang KT, Underwood KF, Lee CJ, Whipple RA, Jewell CM, Ory E, Thompson KN, Ju JA, Mathias TJ, Pratt SJP, Vitolo MI, Martin SS. (2021) Lipid tethering of breast tumor cells reduces cell aggregation during mammosphere formation. Sci Rep. 11(1):3214.
  5. Pratt SJP, Hernández-Ochoa E, Martin SS. (2020) Calcium signaling: breast cancer’s approach to manipulation of cellular circuitry.  Biophys Rev. 12(6):1343-1359.
  6. Ju J.A., Lee C.J., Thompson, K.N., Ory, E.C., Lee, R.M., Mathias, T.J., Pratt, S.J.P., Vitolo, M.I., Jewell, C.M., Martin, S.S. (2020) Partial thermal imidization of polyelectrolyte multilayer cell tethering surfaces (TetherChip) enables efficient cell capture and microtentacle fixation for circulating tumor cell analysis.  Lab on a Chip 20(16):2872-2888. 
  7. Wong BS, Shah SR, Yankaskas CL, Bajpai VK, Wu PH, ChinD , Ifemembi B, ReFaey K, Schiapparelli P, Zheng X, Martin SS, Fan CM, Quiñones-Hinojosa A, Konstantopoulos, K.. A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma.  Nat Biomed Eng. 2020 Sep 28. doi: 10.1038/s41551-020-00621-9.
  8. Pratt SJP, Lee RM, Chang KT, Hernández-Ochoa EO, Annis DA, Ory EC, Thompson KN, Bailey PC, Mathias TJ, Ju JA, Vitolo MI, Schneider MF, Stains JP, Ward CW, Martin SS  (2020)   Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca2+ signals that are inhibited by oncogenic KRas. Proc. Natl. Acad. Sci. USA 20;117(42):26008-26019.
  9. Pratt SJP, Lee RM, Martin SS. (2020) The Mechanical Microenvironment in Breast Cancer. Cancers (Basel). 12(6):E1452. doi: 10.3390/cancers12061452.
  10. Mathias TJ, Chang KT, Martin SS, Vitolo MI. (2020) Gauging the Impact of Cancer Treatment Modalities on Circulating Tumor Cells (CTCs).Cancers (Basel). 12(3)743. PubMed PMID: 32245166.
  11. Rahmanto, Y.S.,  Wenjing Shen, W., Shi,X., Chen, X., Yu, Y., Yu, Z.C., Miyamoto, T., Lee, M., Singh, V., Asaka, R., Shimberg, G., Vitolo, M.I., Martin, S.S., Wirtz, D., Drapkin, R., Xuan, J., Wang, T.L. and Shih, I.M. (2020) Inactivation of Arid1a in the Endometrium is Associated with Endometrioid Tumorigenesis through Transcriptional Reprogramming. Nature Communications 11(1):2717. doi: 10.1038/s41467-020-16416-0.
  12. Bailey PC, Martin SS. (2019) Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology. Cells. 8(6). doi: 10.3390/cells8060553. Review. PubMed PMID: 31174404
  13. Yankaskas CL, Thompson KN, Paul CD, Vitolo MI, Mistriotis P, Mahendra A, Bajpai VK, Shea DJ, Manto KM, Chai AC, Varadarajan N, Kontrogianni-Konstantopoulos A, Martin SS, Konstantopoulos K. (2019) A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens. Nat Biomed Eng. 2019 May 6. doi: 10.1038/s41551-019-0400-9.
  14. Kallergi G, Aggouraki D, Zacharopoulou N, Stournaras C, Georgoulias V, Martin SS. (2018) Evaluation of α-tubulin, detyrosinated α-tubulin, and vimentin in CTCs: identification of the interaction between CTCs and blood cells through cytoskeletal elements.Breast Cancer Res. 20(1):67. doi: 10.1186/s13058-018-0993-z.
  15. Bailey PC, Lee RM, Vitolo MI, Pratt SJP, Ory E, Chakrabarti K, Lee CJ, Thompson KN, Martin SS. (2018) Single-Cell Tracking of Breast Cancer Cells Enables Prediction of Sphere Formation from Early Cell Divisions.  iScience. 8:29-39.
  16. Kessler MD, Pawar NR, Martin SS, Antalis TM, O’Connor TD. Improving Cancer Detection and Treatment with Liquid Biopsies and ptDNA.  Trends Cancer. 2018 Sep;4(9):643-654. doi: 10.1016/j.trecan.2018.07.004. Epub 2018 Aug 1. Review.
  17. Pratt SJP, Hernández-Ochoa EO, Lee RM, Ory EC, Lyons JS, Joca HC, Johnson A, Thompson K, Bailey P, Lee CJ, Mathias T, Vitolo MI, Trudeau M, Stains JP, Ward CW, Schneider MF, Martin SS. Real-time scratch assay reveals mechanisms of early calcium signaling in breast cancer cells in response to wounding.  Oncotarget. 9(38):25008-25024.
  18. Yu Y, Suryo Rahmanto Y, Lee MH, Wu PH, Phillip JM, Huang CH, Vitolo MI, Gaillard S, Martin SS, Wirtz D, Shih IM, Wang TL. (2018) Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway.  Oncogene 37(28):3778-3789.
  19. Lyons JS, Joca HC, Law RA, Williams KM, Kerr JP, Shi G, Khairallah RJ, Martin SS, Konstantopoulos K, Ward CW, Stains JP. Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes.  Science Signaling 10(506). pii: eaan5748. doi: 10.1126/scisignal.aan5748.
  20. Ory EC, Bhandary L, Boggs AE, Chakrabarti KR, Parker J, Losert W, Martin SS. (2017) Analysis of microtubule growth dynamics arising from altered actin network structure and contractility in breast tumor cells. Physical Biol. 14(2):026005. doi: 10.1088/1478-3975/aa59a2.
  21. Ory E.C., Chen D, Chakrabarti KR, Zhang P, Andorko JI, Jewell CM, Losert W, Martin SS. (2017) Extracting microtentacle dynamics of tumor cells in a non-adherent environment. Oncotarget 8:111567-80.
  22. Adams D.L., Adams D.K., Stefansson S., Haudenschild C., Martin S.S., Charpentier M., Chumsri S., Cristofanilli M., Tang C.M., Alpaugh R.K. (2016) Mitosis in circulating tumor cells stratifies highly aggressive breast carcinomas. Breast Cancer Res. 18(1):44.
  23. Adams D.L., Adams D.K., Alpaugh R.K., Cristofanilli M., Martin S.S., Chumsri S., Tang C.M., Marks J.R. (2016)  Circulating Cancer Associated Macrophage-Like Cells Differentiate Malignant Breast Cancer and Benign Breast Conditions.Cancer Epidemiol Biomarkers Prev. 25(7):1037-42.
  24. Adams, D.L., Alpaugh, R.K., Martin, S.S., Charpentier, M., Chumsri, S., Cristofanilli, M., Adams, D.K., Makarova, O.V., Zhu, P., Li, S.,  Tang, C.M., Stefanssoni, S. (2016)  Precision microfilters as an all in one system for multiplex analysis of circulating tumor cells. RSC Advances.  6: 6405-6414.
  25. Chakrabarti, K.R., Andorko, J.I., Whipple, R.A., Zhang, P., Sooklal, E.L., Martin, S.S., Jewell, C.M. (2016) Lipid tethering of breast tumor cells enables real-time imaging of free-floating cell dynamics and drug response. Oncotarget 7(9):10486-97. (Cover).

Previous Publications 2007-2015

  1. Chakrabarti, K.R., Lindsay Hessler, L.K., Bhandary, L., and Martin, S.S. (2015).  Molecular Pathways: New Signaling Considerations When Targeting Cytoskeletal Balance to Reduce Tumor Growth. Clinical Cancer Research – Invited review 21(23):5209-14.
  2. Thompson, K.N., Whipple, R.A., Yoon, J.R., Lipsky, M., Charpentier, M.S., Boggs, A.E., Chakrabarti, K.R., Bhandary, L., Hessler, L.K., and Martin, S.S., and Vitolo, M.I. (2015).  The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence. Oncotarget 6(34):35231-46..
  3. Chakrabarti, K.R., Whipple, R.A., Boggs, A.E., Hessler, L.K., Bhandary, L., Vitolo, M.I., Thompson, K.N., and Martin, S.S. (2015).  Pharmacologic regulation of AMPK in breast cancer affects cytoskeletal properties involved with microtentacle formation and re-attachment. Oncotarget 6(34):36292-307.
  4. Kerr, J.P., Robison, P., Shi, G., Bogush, A.I., Kempema, A.M., Hexum, J.K., Becerra, N., Harki, D.A., Martin, S.S., Ratieri, R., Prosser, B.L., Ward, C.W. (2015). Detyrosinated Microtubules Modulate Mechanotransduction in Heart and Skeletal Muscle. Nature Communications 6:8526.
  5. Bhandary, L., Whipple, R.A., Vitolo, M.I., Charpentier, M.S., Boggs, A.E., Thompson, K.N., Chakrabarti, K.R.  and Martin, S.S. (2015).  ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells.  Oncotarget 6(8):6251-66.
  6. Adams, D.L., Martin, S.S., Alpaugh, R.K., Charpentier, M., Tsai, S., Bergan, R.C., Ogden, I.M., Catalona, W., Chumsri, S., Tang, C.M., Cristofanilli, M. (2015).  Cytometric characterization of circulating tumor cells captured by microfiltration and their correlation to the cellsearch CTC test.  Cytometry A 87(2):137-44.
  7. Boggs, A.E., Vitolo, M.I., Whipple, R.A., Charpentier, M.S., Goloubeva, O.G., Ioffe, O.B., Tuttle, K.C., Slovic, J., Lu, Y., Mills, G.B., Martin, S.S. (2015). α-tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion and invasive migration.  Cancer Research 75(1):203-15.
  8. Shriver M, Stroka KM, Vitolo MI, Martin S, Huso DL, Konstantopoulos K, Kontrogianni-Konstantopoulos A. (2015).  Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis. Oncogene 34(32):4248-59.
  9. Perry N.A., Vitolo M.I., MartinS.S., Kontrogianni-Konstantopoulos A. (2014). Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells. Oncotarget 5(18): 8558-68.
  10. Kenchegowda, D. Hongbin Liu, H., Thompson, K., Luo, L., Martin, S.S., and Fisher, S.A. (2014) Vulnerability of the developing heart to oxygen deprivation as a cause of congenital heart defects. J Am Heart Assoc. 3(3):e000841.
  11. Hartman, K.G., Vitolo, M.I., Pierce, A.D., Fox, J.M., Shapiro, P., Martin, S.S., Wilder, P., Weber, D. (2014) Complex formation between S100B and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is Ca2+-dependent and inhibits ERK-mediated phosphorylation of RSK.J. Biol. Chem. 289(18):12886-95.
  12. Kundu, N., Ma, X., Kochel, T.,  Goloubeva, O., Staats, P., Thompson, K., Martin, S.S., Reader, J., Take, Y. Collin, P., Fulton, A. (2014) Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties. Breast Cancer Res Treat. 143(1):19-31.
  13. Adams, D.L., Martin, S.S., Alpaugh, R.K., Charpentier, M., Tsai, S., Bergan, R.C., Ogden, I.M., Catalona, W., Chumsri, S., Tang, C.M., Cristofanilli, M. (2014) Circulating giant macrophages as a potential biomarker of solid tumors. Proc Natl Acad Sci U S A. 111(9):3514-9.
  14. Adams, D.,Zhu, P., Makarova, O.V., Martin, S.S., Charpentier, M., Chumsri, S., Li, S., Amstutz, P., Tang, C.M. (2014)The Systematic Study of Circulating Tumor Cell Isolation using Lithographic Microfilters. Royal Society of Chemistry (RSC) Advances.  4:4334-42.
  15. Charpentier, M.S., Whipple, R.A., Vitolo, M.I., Boggs, A.E., Slovic, J., Thompson, K.N., Bhandary, L., Martin, S.S. (2014)  Curcumin targets breast cancer stem-like cells with microtentacles that persist in mammospheres and promote reattachment. Cancer Research 74(4):1250-60.
  16. Charpentier, M., Martin S.S. (2013) Interplay of Stem Cell Characteristics, EMT, and Microtentacles in Circulating Breast Tumor Cells. Cancers (Basel). 14;5(4):1545-65.
  17. Whipple, R.A., Vitolo, M.I., Boggs, A.E., Charpentier, M.S., Thompson, K., Martin, S.S. (2013) Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF‐κB inhibition. Breast Cancer Research 15(5):R83.
  18. Zhou, H., Hittelman, W.N., Yagita, H., Cheung, L.H., Martin, S.S., Winkles, J.A., Rosenblum M.G. (2013).  Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors.  Cancer Research (14):4439-50.
  19. Vitolo. M.I., Boggs, A.E., Whipple, R.A., Yoon, J.R., Thompson, K., Matrone, M.A., Cho, E.H., Balzer, E.M., Martin, S.S. (2013).  Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin. Oncogene 32(17):2200-10.
  20. Kiessling, T.R., Herrera, M., Nnetu, K.D., Balzer, E.M.,  Girvan, M., Fritsch, A., Martin, S.S., Kaes, J., Losert, W. (2013) Ref.:  Ms. No. EBJO-D-12-00135R1 Analysis of Multiple Physical Parameters for Mechanical Phenotyping of Living Cells. Eur. Biophy. J. 42(5):383-94.
  21. Guha, P., Kaptan, E., Bandyopadhyaya, G., Kaczanowska, S., Davila, E., Thompson, K., Martin, S.S., Kalvakolanu, D.V., Vasta, G.R., Ahmed, H. (2013).  Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis. Proc. Natl. Acad. Sci. USA. 110(13):5052-7.
  22. Kamarajugadda, S., Cai, Q., Chen, H., Nayak, S., Zhu, J., He, M., Jin, Y., Zhang, Y., Ai1, L., Martin, S.S., Tan, M., Lu, J. (2013). Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis. Cell Death and Disease 4:e504.
  23. Varghese, S., Whipple, R.A., Martin, S.S., Alexander, R.H. (2012). Multipotent Cancer Stem Cells Derived from Human Malignant Peritoneal Mesothelioma Promote Tumorigenesis  PLOS One 7(12):e52825.
  24. Clerc, P., Carey, G.B., Mehrabian, Z., Wei, M., Hwang, H., Girnun, G., Chen, H., Martin, S.S., Polster, B.M. (2012) Rapid Detection of an ABT-737-sensitive Primed for Death State in Cells Using Microplate-based Respirometry.PLOS One 7(8):e42487.
  25. Balzer, E.M., Tong, Z., Paul, C.D., Hung, W.C., Stroka, K.M., Boggs, A.E., Martin S.S., Kostantopoulos, K. (2012).  Physical confinement alters tumor cell adhesion and migration phenotypes.  FASEB J. 26(10):4045-56.
  26. Scharadin T.M., Jiang H., Martin S.S., Eckert R.L. (2012). TIG3 Interaction at the Centrosome Alters Microtubule Distribution and Centrosome Function.J.Cell Sci. 125:2604-14.
  27. Tatarov I., Panda A., Petkov D., Kolappaswamy K., Thompson K., Kavirayani A., Lipsky M.M., Elson E., Davis C.C., Martin S.S., DeTolla L.J. (2011).  Effect of magnetic fields on tumor growth and viability.  Comparative Medicine. 61(4):339-45.
  28. Yoon J.R., Whipple R.A., Balzer E.M., Cho E.H., Matrone M.A., Peckham M., Martin S.S. (2011). Local anesthetics inhibit kinesin motility and microtentacle protrusions in human epithelial and breast tumor cells.  Breast Cancer Res Treat. 129(3):691-701.
  29. Hagner, P., Mazan-Mamczarz, K., Dai, B., Balzer, E.M., Martin, S.S., Corl, S., Zhao, X., Gartenhaus, R.B. (2011).Ribosomal protein S6 is highly expressed in lymphoma and associates with mRNA containing a 5′ terminal oligopyrimidine tract. Oncogene 30:1531-41.
  30. Zheng, D., Niu, S., Zhan, X.H., Yu, D., Zeng, X., Cui, C., Chen, Y., Yoon, J., Martin, S.S., Lu, X., Zhan, X. (2010). Abba promotes PDGF-mediated membrane ruffling through activation of the small GTPase Rac1.  Biochem Biophys Res Commun. 401(4):527-32.
  31. Matrone, M.A., Whipple, R.A., Balzer, E.M., Martin, S.S. (2010). Microtentacles tip the balance of cytoskeletal forces in circulating tumor cells. Cancer Research – Invited review 70(20):7737-41.
  32. Balzer, E.M., Whipple, R.A., Thompson, K., Boggs, A.E., Slovic, J., Cho, E.H., Matrone, M.A., Yoneda, T., Mueller, S.C., Martin, S.S. (2010). c-Src Differentially Regulates the Functions of  Microtentacles and Invadopodia.Oncogene 29(48):6402-8.
  33. Whipple, R.A., Cho, E.H., Balzer, E.M., Matrone, M.A., Vitolo, M.I., Yoon, J.R., Ioffe, O.B., Tuttle, K.C., Yang, J., Martin, S.S.  (2010) Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement. Cancer Research 70(20):8127-37 (Cover).
  34. Matrone, M.A., Whipple, R.A., Thompson, K., Cho, E.H., Vitolo, M.I.,  Balzer, E.M., Yoon, J.R., Ioffe, O.B., Tuttle, K.C., Tan, M., Martin, S.S.(2010) Metastatic breast tumors express increased tau, which promotes microtentacle formation and the reattachment of detached breast tumor cells.  Oncogene 29(22):3217-27.
  35. Burks, S.R., Macedo, L.F., Barth, E.D., Tkaczuk, K.H., Martin, S.S., Rosen, G.M., Halpern, H.J., Brodie, A.M., Kao, J.P.Y. (2010) Anti-HER2 immunoliposomes for selective delivery of electron paramagnetic resonance imaging probes to HER2-overexpressing breast tumor cells.  Breast Cancer Research and  Treatment 124(1):121-31.
  36. Balzer, E.M., Whipple, R.A., Cho, E.H., Matrone, M.A.,  Yoon, J.R., Martin, S.S. (2010) Anti-mitotic chemotherapeutics promote adhesive responses in detached and circulating tumor cells. Breast Cancer Research and Treatment 121(1):65-78.
  37. Cho, E.H., Whipple, R.A., Matrone, M.A., Balzer, E.M., Martin, S.S. (2010) Delocalization of γ-tubulin due to increased solubility in human breast cancer cell lines. Cancer Biology and Therapy 9(1):66-76.
  38. Vitolo, M.I., Weiss, M.B., Szmacinski, M., Tahir, K., Waldman, T., Park, B.H., Martin, S.S., Weber, D.J.,  Bachman, K.E. (2009)   Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in Human Mammary Epithelial Cells.  Cancer Research 69(21):8275-83.
  39. Sun, P., Nallar, S.C., Kalakonda, S., Lindner, D.J., Martin, S.S., Kalvakolanu, D.V. (2009) GRIM-19 inhibits v-Src-induced cell motility by interfering with cytoskeletal restructuring. Oncogene 28(10):1339-47.
  40. Whipple, R.A., Balzer, E.M., Cho, E.H., Matrone, M.A., Yoon, J.R., Martin, S.S. (2008) Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cells. Cancer Research 68(14):5678-88.
  41. Whipple, R.A., Cheung, A.M., Martin, S.S. (2007) Detyrosinated microtubule protrusions in suspended mammary epithelial cells promote reattachment. Experimental Cell Research 313(7):1326-36.